Ontology highlight
ABSTRACT:
SUBMITTER: Hellemann E
PROVIDER: S-EPMC10044111 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Hellemann Erich E Nallathambi Amrita A Durrant Jacob D JD
Protein science : a publication of the Protein Society 20230401 4
β-lactam antibiotics target DD-transpeptidases, enzymes that perform the last step of bacterial cell-wall synthesis. To block the antimicrobial activity of these antibiotics, bacteria have evolved lactamases that render them inert. Among these, TEM-1, a class A lactamase, has been extensively studied. In 2004, Horn et al. described a novel allosteric TEM-1 inhibitor, FTA, that binds distant from the TEM-1 orthosteric (penicillin-binding) pocket. TEM-1 has subsequently become a model for the stud ...[more]