Proton Radiotherapy for Management of Medulloblastoma: A Systematic Review of Clinical Outcomes.

ABSTRACT:

Purpose

The aim of this study was to comprehensively review all studies examining clinical outcomes of craniospinal irradiation with proton radiotherapy for medulloblastoma (MB) to determine whether theoretical dosimetric advantages have translated into superior clinical outcomes (including survival and toxicities) compared with traditional photon-based techniques.

Methods and materials

We performed a systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Articles reporting on clinical outcomes of pediatric and/or adult patients with MB treated with proton radiotherapy were included. Evidence quality was assessed using a modified Newcastle Ottawa scale and GRADE score.

Results

Thirty-five studies were inc

SUBMITTER: Young S 

PROVIDER: S-EPMC10051027 | biostudies-literature | 2023 Jul-Aug

REPOSITORIES: biostudies-literature