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A Compendium of AR Splice Variants in Metastatic Castration-Resistant Prostate Cancer.

ABSTRACT: Treatment-induced AR alterations, including AR alternative splice variants (AR-Vs), have been extensively linked to harboring roles in primary and acquired resistance to conventional and next-generation hormonal therapies in prostate cancer and therefore have gained momentum. Our aim was to uniformly determine recurrent AR-Vs in metastatic castration-resistant prostate cancer (mCRPC) using whole transcriptome sequencing in order to assess which AR-Vs might hold potential diagnostic or prognostic relevance in future research. This study reports that in addition to the promising AR-V7 as a biomarker, AR45 and AR-V3 were also seen as recurrent AR-Vs and that the presence of any AR-V could be associated with higher AR expression. With future research, these AR-Vs may therefore harbor similar or complementary roles to AR-V7 as predictive and prognostic biomarkers in mCRPC or as proxies for abundant AR expression.

SUBMITTER: Isebia KT

PROVIDER: S-EPMC10053078 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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A Compendium of AR Splice Variants in Metastatic Castration-Resistant Prostate Cancer.

Isebia Khrystany T KT Lolkema Martijn P MP Jenster Guido G de Wit Ronald R Martens John W M JWM van Riet Job J

International journal of molecular sciences 20230322 6

Treatment-induced AR alterations, including AR alternative splice variants (AR-Vs), have been extensively linked to harboring roles in primary and acquired resistance to conventional and next-generation hormonal therapies in prostate cancer and therefore have gained momentum. Our aim was to uniformly determine recurrent AR-Vs in metastatic castration-resistant prostate cancer (mCRPC) using whole transcriptome sequencing in order to assess which AR-Vs might hold potential diagnostic or prognostic ...[more]

PMID: 36983083

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