Gene panel selection for targeted spatial transcriptomics.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC10054990 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Publications
Gene panel selection for targeted spatial transcriptomics.
Zhang Yida Y Petukhov Viktor V Biederstedt Evan E Que Richard R Zhang Kun K Kharchenko Peter V PV
bioRxiv : the preprint server for biology 20230324
Targeted spatial transcriptomics hold particular promise in analysis of complex tissues. Most such methods, however, measure only a limited panel of transcripts, which need to be selected in advance to inform on the cell types or processes being studied. A limitation of existing gene selection methods is that they rely on scRNA-seq data, ignoring platform effects between technologies. Here we describe gpsFISH, a computational method to perform gene selection through optimizing detection of known ...[more]
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