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Past, Present, and a Glance into the Future of Multiple Myeloma Treatment.


ABSTRACT: Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free survival for MM patients in the last decade; however, a relapse for most MM patients is inevitable. In this review we discuss current treatment, important pathways for proliferation, survival, immune suppression, and resistance that could be targeted for future treatments.

SUBMITTER: Elbezanti WO 

PROVIDER: S-EPMC10056051 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Past, Present, and a Glance into the Future of Multiple Myeloma Treatment.

Elbezanti Weam Othman WO   Challagundla Kishore B KB   Jonnalagadda Subash C SC   Budak-Alpdogan Tulin T   Pandey Manoj K MK  

Pharmaceuticals (Basel, Switzerland) 20230308 3


Multiple myeloma (MM) is a challenging hematological cancer which typically grows in bone marrow. MM accounts for 10% of hematological malignancies and 1.8% of cancers. The recent treatment strategies have significantly improved progression-free survival for MM patients in the last decade; however, a relapse for most MM patients is inevitable. In this review we discuss current treatment, important pathways for proliferation, survival, immune suppression, and resistance that could be targeted for  ...[more]

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