Ontology highlight
ABSTRACT:
SUBMITTER: Pagani F
PROVIDER: S-EPMC10056194 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Pagani Francesca F Gryzik Magdalena M Somenza Elena E Cominelli Manuela M Balzarini Piera P Schreiber Alberto A Mattavelli Davide D Nicolai Piero P Doglietto Francesco F Poliani Pietro Luigi PL
Journal of personalized medicine 20230227 3
Chordomas are rare primary malignant tumours of notochordal origin usually arising along the axial skeleton with particular predilection of the skull base and sacrococcygeal region. Albeit usually slow-growing, chordomas can be aggressive mostly depending on their invasive behaviour and according to different histotypes and molecular alterations, including <i>TBXT</i> duplication and <i>SMARCB1</i> homozygous deletion. Partial or complete PTEN deficiency has also been observed. PTEN is a negativ ...[more]