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Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives.


ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease; patients' long-term survival is strictly linked to the surgical resection of the tumor but only a minority of patients (2-3%) have a resectable disease at diagnosis. In patients with surgically unresectable disease, interventional radiology is taking on an increasing role in treatment with the application of loco-regional percutaneous therapies. The primary purposes of this narrative review are to analyze the safety and efficacy of ablative techniques in the management of borderline resectable and locally advanced diseases and to underline the role of the interventional radiologist in the management of patients with distant metastases. The secondary purpose is to focus on the synergy between immunotherapy and ablative therapies.

SUBMITTER: Punzi E 

PROVIDER: S-EPMC10059735 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Interventional Radiology in the Treatment of Pancreatic Adenocarcinoma: Present and Future Perspectives.

Punzi Ernesto E   Carrubba Claudio C   Contegiacomo Andrea A   Posa Alessandro A   Barbieri Pierluigi P   De Leoni Davide D   Mazza Giulia G   Tanzilli Alessandro A   Cina Alessandro A   Natale Luigi L   Sala Evis E   Iezzi Roberto R  

Life (Basel, Switzerland) 20230320 3


Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease; patients' long-term survival is strictly linked to the surgical resection of the tumor but only a minority of patients (2-3%) have a resectable disease at diagnosis. In patients with surgically unresectable disease, interventional radiology is taking on an increasing role in treatment with the application of loco-regional percutaneous therapies. The primary purposes of this narrative review are to analyze the safety and efficacy of abl  ...[more]

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