Dataset Information
Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.
Ontology highlight
ABSTRACT: Purpose of review
This review aims to summarize the research on brain activity during affective processing (i.e., reward, negative emotional stimuli, loss) and adolescent substance use (SU).Recent findings
Most research revealed links between altered neural activity in midcingulo-insular, frontoparietal and other network regions and adolescent SU. Increased recruitment of midcingulo-insular regions-particularly the striatum-to positive affective stimuli (e.g., monetary reward) was most often associated with initiation and low-level use of substances, whereas decreased recruitment of these regions was most often associated with SUD and higher risk SU. In regards to negative affective stimuli, most research demonstrated increased recruitment of midcingulo-insular network regions. There is also evidence that these associations may be sex-specific.Summary
Future research should employ longitudinal designs that assess affect-related brain activity prior to and following SU initiation and escalation. Moreover, examining sex as as moderating variable may help clarify if affective neural risk factors are sex-specific.
SUBMITTER: Goncalves SF
PROVIDER: S-EPMC10062006 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Affect-Related Brain Activity and Adolescent Substance Use: A Systematic Review.
Current behavioral neuroscience reports 20220120 1
<h4>Purpose of review</h4>This review aims to summarize the research on brain activity during affective processing (i.e., reward, negative emotional stimuli, loss) and adolescent substance use (SU).<h4>Recent findings</h4>Most research revealed links between altered neural activity in midcingulo-insular, frontoparietal and other network regions and adolescent SU. Increased recruitment of midcingulo-insular regions-particularly the striatum-to positive affective stimuli (e.g., monetary reward) wa ...[more]