Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes.
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ABSTRACT:
SUBMITTER: Ma Q
PROVIDER: S-EPMC10063586 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
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Integration of epigenetic and genetic profiles identifies multiple sclerosis disease-critical cell types and genes.
Ma Qin Q Shams Hengameh H Didonna Alessandro A Baranzini Sergio E SE Cree Bruce A C BAC Hauser Stephen L SL Henry Roland G RG Oksenberg Jorge R JR
Communications biology 20230330 1
Genome-wide association studies (GWAS) successfully identified multiple sclerosis (MS) susceptibility variants. Despite this notable progress, understanding the biological context of these associations remains challenging, due in part to the complexity of linking GWAS results to causative genes and cell types. Here, we aimed to address this gap by integrating GWAS data with single-cell and bulk chromatin accessibility data and histone modification profiles from immune and nervous systems. MS-GWA ...[more]
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