Ontology highlight
ABSTRACT:
SUBMITTER: Fu JF
PROVIDER: S-EPMC10063833 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Fu Jessie Fanglu JF Lois Cristina C Sanchez Justin J Becker J Alex JA Rubinstein Zoe B ZB Thibault Emma E Salvatore Andrew N AN Sari Hasan H Farrell Michelle E ME Guehl Nicolas J NJ Normandin Marc D MD Fakhri Georges El GE Johnson Keith A KA Price Julie C JC
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20221124 4
[<sup>18</sup>F]MK-6240 meningeal/extracerebral off-target binding may impact tau quantification. We examined the kinetics and longitudinal changes of extracerebral and reference regions. [<sup>18</sup>F]MK-6240 PET was performed in 24 cognitively-normal and eight cognitively-impaired subjects, with arterial samples in 13 subjects. Follow-up scans at 6.1 ± 0.5 (n = 25) and 13.3 ± 0.9 (n = 16) months were acquired. Extracerebral and reference region (cerebellar gray matter (CerGM)-based, cerebral ...[more]