Dataset Information

Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.

ABSTRACT:

Introduction

Early-onset colorectal cancer diagnosed before the age of 50 years has been increasing. Likely reflecting the pathogenic role of the intestinal microbiome, which gradually changes across the entire colorectal length, the prevalence of certain tumor molecular characteristics gradually changes along colorectal subsites. Understanding how colorectal tumor molecular features differ by age and tumor location is important in personalized patient management.

Methods

Using 14,004 cases with colorectal cancer including 3,089 early-onset cases, we examined microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF mutations in carcinomas of the cecum, ascending colon, transverse colon, descending colon, sigmoid colon, and rectum and compared early-onset cases with later-onset cases.

Results

The proportions of MSI-high, CIMP-high, and BRAF -mutated early-onset tumors were lowest in the rectum (8.8%, 3.4%, and 3.5%, respectively) and highest in the ascending colon (46% MSI-high; 15% CIMP-high) or transverse colon (8.6% BRAF -mutated) (all Ptrend <0.001 across the rectum to ascending colon). Compared with later-onset tumors, early-onset tumors showed a higher prevalence of MSI-high status and a lower prevalence of CIMP-high status and BRAF mutations in most subsites. KRAS mutation prevalence was higher in the cecum compared with that in the other subsites in both early-onset and later-onset tumors ( P < 0.001). Notably, later-onset MSI-high tumors showed a continuous decrease in KRAS mutation prevalence from the rectum (36%) to ascending colon (9%; Ptrend <0.001), followed by an increase in the cecum (14%), while early-onset MSI-high cancers showed no such trend.

Discussion

Our findings support biogeographical and pathogenic heterogeneity of colorectal carcinomas in different colorectal subsites and age groups.

SUBMITTER: Ugai T

PROVIDER: S-EPMC10065351 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.

Ugai Tomotaka T Haruki Koichiro K Harrison Tabitha A TA Cao Yin Y Qu Conghui C Chan Andrew T AT Campbell Peter T PT Akimoto Naohiko N Berndt Sonja S Brenner Hermann H Buchanan Daniel D DD Chang-Claude Jenny J Fujiyoshi Kenji K Gallinger Steven J SJ Gunter Marc J MJ Hidaka Akihisa A Hoffmeister Michael M Hsu Li L Jenkins Mark A MA Milne Roger L RL Moreno Victor V Newcomb Polly A PA Nishihara Reiko R Pai Rish K RK Sakoda Lori C LC Slattery Martha L ML Sun Wei W Amitay Efrat L EL Alwers Elizabeth E Thibodeau Stephen N SN Toland Amanda E AE Van Guelpen Bethany B Woods Michael O MO Zaidi Syed H SH Potter John D JD Giannakis Marios M Song Mingyang M Nowak Jonathan A JA Phipps Amanda I AI Peters Ulrike U Ogino Shuji S

The American journal of gastroenterology 20221230 4

<h4>Introduction</h4>Early-onset colorectal cancer diagnosed before the age of 50 years has been increasing. Likely reflecting the pathogenic role of the intestinal microbiome, which gradually changes across the entire colorectal length, the prevalence of certain tumor molecular characteristics gradually changes along colorectal subsites. Understanding how colorectal tumor molecular features differ by age and tumor location is important in personalized patient management.<h4>Methods</h4>Using 14 ...[more]

PMID: 36707929

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Dataset Information

Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.

Introduction

Methods

Results

Discussion

Publications

Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.

Similar Datasets

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