Ontology highlight
ABSTRACT:
SUBMITTER: Mascarau R
PROVIDER: S-EPMC10067447 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Mascarau Rémi R Woottum Marie M Fromont Léa L Gence Rémi R Cantaloube-Ferrieu Vincent V Vahlas Zoï Z Lévêque Kevin K Bertrand Florent F Beunon Thomas T Métais Arnaud A El Costa Hicham H Jabrane-Ferrat Nabila N Gallois Yohan Y Guibert Nicolas N Davignon Jean-Luc JL Favre Gilles G Maridonneau-Parini Isabelle I Poincloux Renaud R Lagane Bernard B Bénichou Serge S Raynaud-Messina Brigitte B Vérollet Christel C
The Journal of cell biology 20230329 5
Macrophages are essential for HIV-1 pathogenesis and represent major viral reservoirs. Therefore, it is critical to understand macrophage infection, especially in tissue macrophages, which are widely infected in vivo, but poorly permissive to cell-free infection. Although cell-to-cell transmission of HIV-1 is a determinant mode of macrophage infection in vivo, how HIV-1 transfers toward macrophages remains elusive. Here, we demonstrate that fusion of infected CD4+ T lymphocytes with human macrop ...[more]