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Seminal plasma metabolomics signatures of normosmic congenital hypogonadotropic hypogonadism.


ABSTRACT:

Background

Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare disease, whose pathogenesis remains unclear. Here, we conducted untargeted metabolomics and lipidomics to identify seminal plasma signatures of nCHH, and to study the effect of LH and FSH deficiency on semen.

Methods

Twenty-five diagnosed patients with nCHH (HH group) and twenty-three healthy participants (HC group) were enrolled. Laboratory parameters, seminal plasma samples and patients' medical data were collected. Untargeted metabolomics and lipidomic profiling were performed using mass spectrometry (MS).

Results

The metabolomics profiling are altered among patients with nCHH and healthy controls. There are 160 kinds of differential metabolites and the main different lipid species are TAG, PC, SM and PE.

Conclusions

The metabolomics profiles in patients with nCHH changed. We hope that this work provides important insights into the pathophysiology of nCHH.

SUBMITTER: Li X 

PROVIDER: S-EPMC10070097 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Seminal plasma metabolomics signatures of normosmic congenital hypogonadotropic hypogonadism.

Li Xiaogang X   Guo Ye Y   Wang Xi X   Li Haolong H   Mao Jiangfeng J   Yan Songxin S   Luo Guoju G   Wang Renzhi R   Wu Xueyan X   Li Yongzhe Y  

Heliyon 20230323 4


<h4>Background</h4>Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare disease, whose pathogenesis remains unclear. Here, we conducted untargeted metabolomics and lipidomics to identify seminal plasma signatures of nCHH, and to study the effect of LH and FSH deficiency on semen.<h4>Methods</h4>Twenty-five diagnosed patients with nCHH (HH group) and twenty-three healthy participants (HC group) were enrolled. Laboratory parameters, seminal plasma samples and patients' medical data  ...[more]

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