Ontology highlight
ABSTRACT:
SUBMITTER: Ganz T
PROVIDER: S-EPMC10070284 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Ganz Tomas T Nemeth Elizabeta E Rivella Stefano S Goldberg Paul P Dibble Andrew R AR McCaleb Michael L ML Guo Shuling S Monia Brett P BP Barrett Terrance D TD
Advances in therapy 20230123 4
TMPRSS6 is a serine protease highly expressed in the liver. Its role in iron regulation was first reported in 2008 when mutations in TMPRSS6 were shown to be the cause of iron-refractory iron deficiency anemia (IRIDA) in humans and in mouse models. TMPRSS6 functions as a negative regulator of the expression of the systemic iron-regulatory hormone hepcidin. Over the last decade and a half, growing understanding of TMPRSS6 biology and mechanism of action has enabled development of new therapeutic ...[more]