Dataset Information

Contribution of macromolecules to brain ¹ H MR spectra: Experts' consensus recommendations.

ABSTRACT: Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower peaks of metabolites and often complicate their quantification but they also may have potential importance as biomarkers in specific diseases. Thus, separation of broad MM signals from low molecular weight metabolites enables accurate determination of metabolite concentrations and is of primary interest in many studies. Other studies attempt to understand the origin of the MM spectrum, to decompose it into individual spectral regions or peaks and to use the components of the MM spectrum as markers of various physiological or pathological conditions in biomedical research or clinical practice. The aim of this consensus paper is to provide an overview and some recommendations on how to handle the MM signals in different types of studies together with a list of open issues in the field, which are all summarized at the end of the paper.

SUBMITTER: Cudalbu C

PROVIDER: S-EPMC10072289 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Contribution of macromolecules to brain <sup>1</sup> H MR spectra: Experts' consensus recommendations.

Cudalbu Cristina C Behar Kevin L KL Bhattacharyya Pallab K PK Bogner Wolfgang W Borbath Tamas T de Graaf Robin A RA Gruetter Rolf R Henning Anke A Juchem Christoph C Kreis Roland R Lee Phil P Lei Hongxia H Marjańska Małgorzata M Mekle Ralf R Murali-Manohar Saipavitra S Považan Michal M Rackayová Veronika V Simicic Dunja D Slotboom Johannes J Soher Brian J BJ Starčuk Zenon Z Starčuková Jana J Tkáč Ivan I Williams Stephen S Wilson Martin M Wright Andrew Martin AM Xin Lijing L Mlynárik Vladimír V

NMR in biomedicine 20201125 5

Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description of the main MM is provided in this consensus paper. These broad peaks of MM underlie the narrower peaks of metabolites and often complicate their quantification but they also may have potential importance as biomarkers in specific diseases. Thus, separation of broad MM signals from low molecular weight metabolites enables accurate determin ...[more]

PMID: 33236818

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Project description:Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions which result in subtle metabolite changes, the limitations of vendor-provided MRS protocols are increasingly recognized, especially when used at high fields (≥3 T) where chemical shift displacement errors, B0 and B1 inhomogeneities and limitations in the transmit B1 field become prominent. To overcome the limitations of conventional MRS protocols at 3 and 7 T, the use of advanced MRS methodology, including pulse sequences and adjustment procedures, is recommended. Specifically, the semiadiabatic LASER sequence is recommended when TE values of 25-30 ms are acceptable, and the semiadiabatic SPECIAL sequence is suggested as an alternative when shorter TE values are critical. The magnetic field B0 homogeneity should be optimized and RF pulses should be calibrated for each voxel. Unsuppressed water signal should be acquired for eddy current correction and preferably also for metabolite quantification. Metabolite and water data should be saved in single shots to facilitate phase and frequency alignment and to exclude motion-corrupted shots. Final averaged spectra should be evaluated for SNR, linewidth, water suppression efficiency and the presence of unwanted coherences. Spectra that do not fit predefined quality criteria should be excluded from further analysis. Commercially available tools to acquire all data in consistent anatomical locations are recommended for voxel prescriptions, in particular in longitudinal studies. To enable the larger MRS community to take advantage of these advanced methods, a list of resources for these advanced protocols on the major clinical platforms is provided. Finally, a set of recommendations are provided for vendors to enable development of advanced MRS on standard platforms, including implementation of advanced localization sequences, tools for quality assurance on the scanner, and tools for prospective volume tracking and dynamic linear shim corrections.

Dataset Information

Contribution of macromolecules to brain ¹ H MR spectra: Experts' consensus recommendations.

Publications

Contribution of macromolecules to brain <sup>1</sup> H MR spectra: Experts' consensus recommendations.

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Contribution of macromolecules to brain 1 H MR spectra: Experts' consensus recommendations.

Publications

Contribution of macromolecules to brain <sup>1</sup> H MR spectra: Experts' consensus recommendations.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Contribution of macromolecules to brain ¹ H MR spectra: Experts' consensus recommendations.