Dataset Information

Poor sleep pattern is associated with metabolic disorder during transition from adolescence to adulthood.

ABSTRACT:

Objective

The purpose of this study was to investigate whether sleep pattern is associated with metabolic disorders among young adults.

Methods

We measured sleep patterns using multiple sleep behaviors in an ongoing prospective cohort among college students (n = 1,151). At baseline, 729 college students provided fasting blood samples and human body morphological measurements for quantification of metabolic parameters. Then, 340 participants continued to take metabolic parameters measurements at a 2-year follow-up. Sleep patterns were defined by chronotype, sleep duration, insomnia, snoring, and daytime sleepiness. Metabolic scores were derived for four metabolic parameters including body mass index (BMI), waist circumference (WC), fasting blood sugar (FBG), and insulin. Multivariate linear regression model was applied to analyze the association between sleep pattern types and metabolic parameters and metabolic scores.

Results

In the baseline survey, we found that a total of 41 (4.1%) participants had poor sleep patterns. Then, metabolic scores were significantly higher among college students with poor sleep patterns, compared with those who with healthy sleep patterns at baseline (1.00 ± 0.96 vs. 0.78 ± 0.72, p < 0.05) and 2-year follow-up (0.34 ± 0.65 vs. 1.50 ± 1.64, p < 0.05). After covariates were adjusted, poor sleep pattern (β = 0.22, 95% CI: 0.06~2.53, p = 0.001) was associated with elevated metabolic scores at the 2-year follow-up.

Conclusions

The elevated metabolic burden observed in college students with poor sleep patterns highlights the need to identify and address sleep problems in order to minimize the long-term impact on disease vulnerability.

SUBMITTER: Zhang D

PROVIDER: S-EPMC10073678 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Poor sleep pattern is associated with metabolic disorder during transition from adolescence to adulthood.

Zhang Dan D Yang Yajuan Y Zhai Shuang S Qu Yang Y Li Tingting T Xie Yang Y Tao Shuman S Zou Liwei L Tao Fangbiao F Wu Xiaoyan X

Frontiers in endocrinology 20230322

<h4>Objective</h4>The purpose of this study was to investigate whether sleep pattern is associated with metabolic disorders among young adults.<h4>Methods</h4>We measured sleep patterns using multiple sleep behaviors in an ongoing prospective cohort among college students (n = 1,151). At baseline, 729 college students provided fasting blood samples and human body morphological measurements for quantification of metabolic parameters. Then, 340 participants continued to take metabolic parameters m ...[more]

PMID: 37033270

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Project description:ImportanceThe prescribing of stimulant medications for attention-deficit/hyperactivity disorder (ADHD) has increased in the US. Prescription stimulants are one of the most commonly misused controlled substances during adolescence. Despite a 10-fold increase in stimulant-related overdose deaths in the past decade, the transitions from prescription stimulants to illicit stimulants (eg, cocaine, methamphetamine) remain relatively unknown in longitudinal population-based studies.ObjectiveTo determine the longitudinal transitions from adolescents' prescription stimulant exposure (ie, stimulant therapy for ADHD and prescription stimulant misuse [PSM]) to later cocaine and methamphetamine use during young adulthood.Design, setting, and participantsNational longitudinal multicohort panels of US 12th grade public and private school students in the coterminous US were assessed annually (baseline cohort years 2005-2017 [between March and June]) and followed up across 3 waves over a 6-year period to 23 to 24 years of age (follow-up years 2011-2021 [between April and October]).ExposureHistory of self-reported stimulant therapy for ADHD at baseline.Main outcomes and measuresIncidence and prevalence of past-year use of cocaine and methamphetamine during young adulthood (19-24 years of age).ResultsAmong 5034 students enrolled at baseline (2589 [52.0%] female), 470 (10.2% [95% CI, 9.4%-11.2%]) reported use of stimulant therapy for ADHD, 671 (14.6% [95% CI, 13.5%-15.6%]) reported PSM only, and 3459 (75.2% [95% CI, 73.9%-76.4%]) reported neither (and served as population controls). In controlled analyses, there were no statistically significant differences between adolescents who reported stimulant therapy for ADHD at baseline compared with population controls in the adjusted odds of transitioning to later cocaine or methamphetamine initiation or use during young adulthood (19-24 years of age). In contrast, PSM during adolescence in those not treated with stimulants for ADHD had significantly higher odds of transitioning to later cocaine or methamphetamine initiation and use during young adulthood compared with population controls (adjusted odds ratio, 2.64 [95% CI, 1.54-4.55]).Conclusions and relevanceIn this multicohort study, adolescents' stimulant therapy for ADHD was not associated with increased risk of later cocaine and methamphetamine use during young adulthood. Adolescents' prescription stimulant misuse offered a signal for subsequent cocaine or methamphetamine use and warrants monitoring and screening.

Dataset Information

Poor sleep pattern is associated with metabolic disorder during transition from adolescence to adulthood.

Objective

Methods

Results

Conclusions

Publications

Poor sleep pattern is associated with metabolic disorder during transition from adolescence to adulthood.

Similar Datasets

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