Ontology highlight
ABSTRACT:
SUBMITTER: Wang JX
PROVIDER: S-EPMC10077485 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Wang Jia-Xing JX Cao Bo B Ma Ning N Wu Kun-Yi KY Chen Wan-Bing WB Wu Weiju W Dong Xia X Liu Cheng-Fei CF Gao Ya-Feng YF Diao Teng-Yue TY Min Xiao-Yun XY Yong Qing Q Li Zong-Fang ZF Zhou Wuding W Li Ke K
JCI insight 20230308 5
Collectin-11 (CL-11) is a recently described soluble C-type lectin that has distinct roles in embryonic development, host defence, autoimmunity, and fibrosis. Here we report that CL-11 also plays an important role in cancer cell proliferation and tumor growth. Melanoma growth was found to be suppressed in Colec11-/- mice in a s.c. B16 melanoma model. Cellular and molecular analyses revealed that CL-11 is essential for melanoma cell proliferation, angiogenesis, establishment of more immunosuppres ...[more]