Ontology highlight
ABSTRACT:
SUBMITTER: Rosado-Ramos R
PROVIDER: S-EPMC10079842 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Rosado-Ramos Rita R Poças Gonçalo M GM Marques Daniela D Foito Alexandre A M Sevillano David D Lopes-da-Silva Mafalda M Gonçalves Luís G LG Menezes Regina R Ottens Marcel M Stewart Derek D Ibáñez de Opakua Alain A Zweckstetter Markus M Seabra Miguel C MC Mendes César S CS Outeiro Tiago Fleming TF Domingos Pedro M PM Santos Cláudia N CN
Nature communications 20230406 1
Parkinson's Disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide for which there are only symptomatic therapies. Small molecules able to target key pathological processes in PD have emerged as interesting options for modifying disease progression. We have previously shown that a (poly)phenol-enriched fraction (PEF) of Corema album L. leaf extract modulates central events in PD pathogenesis, namely α-synuclein (αSyn) toxicity, aggregation and clearance. PEF w ...[more]