Ontology highlight
ABSTRACT:
SUBMITTER: Yamazaki H
PROVIDER: S-EPMC10081994 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Nature communications 20230407 1
Bombyx Vasa (BmVasa) assembles non-membranous organelle, nuage or Vasa bodies, in germ cells, known as the center for Siwi-dependent transposon silencing and concomitant Ago3-piRISC biogenesis. However, details of the body assembly remain unclear. Here, we show that the N-terminal intrinsically disordered region (N-IDR) and RNA helicase domain of BmVasa are responsible for self-association and RNA binding, respectively, but N-IDR is also required for full RNA-binding activity. Both domains are e ...[more]