Ontology highlight
ABSTRACT:
SUBMITTER: Kim BS
PROVIDER: S-EPMC10087456 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Kim Brian S BS Inan Saadet S Ständer Sonja S Sciascia Thomas T Szepietowski Jacek C JC Yosipovitch Gil G
Experimental dermatology 20220923 12
Modern genetic approaches in animal models have unveiled novel itch-specific neural pathways, emboldening a paradigm in which drugs can be developed to selectively and potently target itch in a variety of chronic pruritic conditions. In recent years, kappa-opioid receptors (KORs) and mu-opioid receptors (MORs) have been implicated in both the suppression and promotion of itch, respectively, by acting on both the peripheral and central nervous systems. The precise mechanisms by which agents that ...[more]