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Role of kappa-opioid and mu-opioid receptors in pruritus: Peripheral and central itch circuits.


ABSTRACT: Modern genetic approaches in animal models have unveiled novel itch-specific neural pathways, emboldening a paradigm in which drugs can be developed to selectively and potently target itch in a variety of chronic pruritic conditions. In recent years, kappa-opioid receptors (KORs) and mu-opioid receptors (MORs) have been implicated in both the suppression and promotion of itch, respectively, by acting on both the peripheral and central nervous systems. The precise mechanisms by which agents that modulate these pathways alleviate itch remains an active area of investigation. Notwithstanding this, a number of agents have demonstrated efficacy in clinical trials that influence both KOR and MOR signalling. Herein, we summarize a number of opioid receptor modulators in development and their promising efficacy across a number of chronic pruritic conditions, such as atopic dermatitis, uremic pruritus and beyond.

SUBMITTER: Kim BS 

PROVIDER: S-EPMC10087456 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Role of kappa-opioid and mu-opioid receptors in pruritus: Peripheral and central itch circuits.

Kim Brian S BS   Inan Saadet S   Ständer Sonja S   Sciascia Thomas T   Szepietowski Jacek C JC   Yosipovitch Gil G  

Experimental dermatology 20220923 12


Modern genetic approaches in animal models have unveiled novel itch-specific neural pathways, emboldening a paradigm in which drugs can be developed to selectively and potently target itch in a variety of chronic pruritic conditions. In recent years, kappa-opioid receptors (KORs) and mu-opioid receptors (MORs) have been implicated in both the suppression and promotion of itch, respectively, by acting on both the peripheral and central nervous systems. The precise mechanisms by which agents that  ...[more]

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