Ontology highlight
ABSTRACT:
SUBMITTER: Lee JE
PROVIDER: S-EPMC10088059 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Lee Jason E JE Cathey Peter I PI Wu Haoxi H Parker Roy R Voeltz Gia K GK
Science (New York, N.Y.) 20200101 6477
Tethered interactions between the endoplasmic reticulum (ER) and other membrane-bound organelles allow for efficient transfer of ions and/or macromolecules and provide a platform for organelle fission. Here, we describe an unconventional interface between membraneless ribonucleoprotein granules, such as processing bodies (P-bodies, or PBs) and stress granules, and the ER membrane. We found that PBs are tethered at molecular distances to the ER in human cells in a tunable fashion. ER-PB contact a ...[more]