PhyloMed: a phylogeny-based test of mediation effect in microbiome.
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ABSTRACT:
SUBMITTER: Hong Q
PROVIDER: S-EPMC10088256 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Publications
PhyloMed: a phylogeny-based test of mediation effect in microbiome.
Hong Qilin Q Chen Guanhua G Tang Zheng-Zheng ZZ
Genome biology 20230411 1
Microbiome data from sequencing experiments contain the relative abundance of a large number of microbial taxa with their evolutionary relationships represented by a phylogenetic tree. The compositional and high-dimensional nature of the microbiome mediator challenges the validity of standard mediation analyses. We propose a phylogeny-based mediation analysis method called PhyloMed to address this challenge. Unlike existing methods that directly identify individual mediating taxa, PhyloMed disco ...[more]
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