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Co-crystal of nadifloxacin with oxalic acid.

ABSTRACT: The 2:1 co-crystal of nadifloxacin [systematic name: 9-fluoro-8-(4-hy-droxy-piperidin-1-yl)-5-methyl-1-oxo-6,7-di-hydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carb-oxy-lic acid] with oxalic acid, C₁₉H₂₁FN₂O₄·0.5C₂H₂O₄, was prepared by slow evaporation from a chloro-form:acetone solvent system. Nadifloxacin belongs to the group of anti-bacterial drugs. The co-crystal is stabilized through an intra-molecular O-H⋯O bond and inter-molecular hydrogen bonds. It was studied by FT-IR spectroscopy, differential scanning calorimetry and X-ray diffraction. Hirshfeld surface analysis indicated that the major contribution to the packing is from O⋯H/H⋯O inter-actions.

SUBMITTER: Karthammaiah GN

PROVIDER: S-EPMC10088309 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Co-crystal of nadifloxacin with oxalic acid.

Karthammaiah Geethanjali N GN Rao Amaraneni Sreenivasa S Solomon Anand K AK

Acta crystallographica. Section E, Crystallographic communications 20230310 Pt 4

The 2:1 co-crystal of nadifloxacin [systematic name: 9-fluoro-8-(4-hy-droxy-piperidin-1-yl)-5-methyl-1-oxo-6,7-di-hydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carb-oxy-lic acid] with oxalic acid, C19H21FN2O4·0.5C2H2O4, was prepared by slow evaporation from a chloro-form:acetone solvent system. Nadifloxacin belongs to the group of anti-bacterial drugs. The co-crystal is stabilized through an intra-molecul ...[more]

PMID: 37057007

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