Fluorescence-guided and molecularly-guided debridement: identifying devitalized and infected tissue in orthopaedic trauma.
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ABSTRACT:
SUBMITTER: Elliott JT
PROVIDER: S-EPMC10091097 | biostudies-literature | 2023 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
Fluorescence-guided and molecularly-guided debridement: identifying devitalized and infected tissue in orthopaedic trauma.
Elliott Jonathan Thomas JT Henderson Eric E Streeter Samuel S SS Demidov Valentin V Han Xinyue X Tang Yue Y Sottosanti J Scott JS Bateman Logan L Brůža Petr P Jiang Shudong S Gitajn I Leah IL
Proceedings of SPIE--the International Society for Optical Engineering 20230101
Following orthopaedic trauma, bone devitalization is a critical determinant of complications such as infection or nonunion. Intraoperative assessment of bone perfusion has thus far been limited. Furthermore, treatment failure for infected fractures is unreasonably high, owing to the propensity of biofilm to form and become entrenched in poorly vascularized bone. Fluorescence-guided surgery and molecularly-guided surgery could be used to evaluate the viability of bone and soft tissue and detect t ...[more]
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