Dataset Information

Fetal thoracic circumference in mid-pregnancy and infant lung function.

ABSTRACT:

Background and aim

Impaired lung function in early infancy is associated with later wheeze and asthma, while fetal thoracic circumference (TC) predicts severity of neonatal lung hypoplasia. Exploring fetal origins of lung function in infancy, we aimed to determine if fetal TC in mid-pregnancy was associated with infant lung function.

Methods

From the prospective Scandinavian general population-based PreventADALL mother-child birth cohort, all 851 3-month-old infants with tidal flow-volume measurements in the awake state and ultrasound fetal size measures at 18 (min-max 16-22) weeks gestational age were included. Associations between fetal TC and time to peak tidal expiratory flow to expiratory time (t_PTEF /t_E ) were analyzed in linear regression models. To account for gestational age variation, we adjusted TC for simultaneously measured general fetal size, by head circumference (TC/HC), abdominal circumference (TC/AC), and femur length (TC/FL). Multivariable models were adjusted for maternal age, maternal asthma, pre-pregnancy body mass index, parity, nicotine exposure in utero, and infant sex.

Results

The infants (47.8% girls) were born at mean (SD) gestational age of 40.2 (1.30) weeks. The mean (SD) t_PTEF /t_E was 0.39 (0.08). The mean (SD) TC/HC was 0.75 (0.04), TC/AC 0.87 (0.04), and TC/FL 4.17 (0.26), respectively. Neither TC/HC nor TC/AC were associated with infant t_PTEF /t_E while a week inverse association was observed between TC/FL and t_PTEF /t_E ( β^$\hat{\beta }$ = -0.03, 95% confidence interval [-0.05, -0.007], p = 0.01).

Conclusion

Mid-pregnancy fetal TC adjusted for fetal head or abdominal size was not associated with t_PTEF /t_E in healthy, awake 3-month-old infants, while a weak association was observed adjusting for fetal femur length.

SUBMITTER: Gudmundsdottir HK

PROVIDER: S-EPMC10091718 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Fetal thoracic circumference in mid-pregnancy and infant lung function.

Gudmundsdóttir Hrefna K HK Hilde Katarina K Bains Karen E S KES Färdig Martin M Haugen Guttorm G LeBlanc Marissa M Nordhagen Live S LS Nordlund Björn B Rehbinder Eva M EM Skjerven Håvard O HO Staff Anne C AC Vettukattil Riyas R Carlsen Karin C L KCL

Pediatric pulmonology 20221011 1

<h4>Background and aim</h4>Impaired lung function in early infancy is associated with later wheeze and asthma, while fetal thoracic circumference (TC) predicts severity of neonatal lung hypoplasia. Exploring fetal origins of lung function in infancy, we aimed to determine if fetal TC in mid-pregnancy was associated with infant lung function.<h4>Methods</h4>From the prospective Scandinavian general population-based PreventADALL mother-child birth cohort, all 851 3-month-old infants with tidal flo ...[more]

PMID: 36097818

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Project description:BackgroundFetal growth is predictive of health later in life. Both toxic and essential metals influence fetal growth, but most studies have focused on these elements individually and used birth weight as an indicator of fetal growth. The objective of the current study was to investigate the impact of a mixture of metals on fetal size in mid-pregnancy in a predominately lower income Hispanic pregnancy cohort in Los Angeles.MethodsFor our primary analysis, we focused on six elements that have previously been associated individually with fetal size, including arsenic (As), barium (Ba), cadmium (Cd), mercury (Hg), molybdenum (Mo), and tin (Sn), measured in maternal urine samples collected in early pregnancy (median: 12.4 weeks gestation). In an exploratory analysis, we additionally included cobalt (Co), nickel (Ni), antimony (Sb), and thallium (Tl). Using covariate-adjusted Bayesian Kernel Machine Regression (BKMR) as our main mixture modeling approach, we examined the impact of these metals on fetal biometry measures obtained between 18 and 22 weeks gestation, with a focus on estimated fetal weight (EFW).ResultsBKMR identified Mo and Ba as the mixture components that contributed most to associations with EFW. Linear associations were observed for both metals. An increase in Mo from the 25th to 75th percentile was associated with a 0.114 (95% credible interval (CI): 0.019, 0.247) SD higher EFW, equivalent to a 7.4 g difference. Similar associations were observed between Mo and the other fetal measures evaluated. In contrast, an increase in Ba from the 25th to 75th percentile was associated with a -0.076 (95% CI: 0.217, 0.066) SD lower EFW, equivalent to a 4.9 g difference. Similar inverse associations were observed for Ba in relation to abdominal circumference and biparietal diameter. BKMR also identified a possible interaction between Ba and Mo in relation to head circumference, suggesting that the positive associations between Mo and this outcome may be attenuated at high levels of Ba, which was consistent with findings from linear regression (Pinteraction = 0.03). In an exploratory analysis accounting for a larger mixture of metals, Mo and Ba consistently contributed most to associations with EFW. An inverse association was also identified between Sb and EFW.ConclusionsOur results suggest that Mo may promote fetal growth, while Ba and Sb may reduce fetal growth, in this population.

Dataset Information

Fetal thoracic circumference in mid-pregnancy and infant lung function.

Background and aim

Methods

Results

Conclusion

Publications

Fetal thoracic circumference in mid-pregnancy and infant lung function.

Similar Datasets

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