Ontology highlight
ABSTRACT:
SUBMITTER: Lucientes-Continente L
PROVIDER: S-EPMC10099856 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Lucientes-Continente Laura L Márquez-Tirado Bárbara B Goicoechea de Jorge Elena E
Immunological reviews 20221116 1
The factor H (FH) protein family is emerging as a complex network of proteins controlling the fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range of diseases including infectious, inflammatory, autoimmune, and degenerative diseases and cancer. Composed, in man, of seven highly related proteins, FH, factor H-like 1, and 5 factor H-related proteins, some of the FH family proteins are devoted to down-regulating the AP, while others exert an opposite function ...[more]