Dataset Information

Sensory impairment and algorithmic classification of early cognitive impairment.

ABSTRACT:

Introduction

Sensory impairment (SI) is linked to cognitive decline, but its association with early cognitive impairment (ECI) is unclear.

Methods

Sensory functions (vision, hearing, vestibular function, proprioception, and olfaction) were measured between 2012 and 2018 in 414 Baltimore Longitudinal Study of Aging (BLSA) participants (age 74 ± 9 years; 55% women). ECI was defined as 1 standard deviation below age-, sex-, race-, and education-specific mean performance in Card Rotations or California Verbal Learning Test immediate recall. Log binomial models (cross-sectional analysis) and Cox regression models (time-to-event analysis) were used to examine the association between SI and ECI.

Results

Cross-sectionally, participants with ≥3 SI had twice the prevalence of ECI (prevalence ratio = 2.10, p = 0.02). Longitudinally, there was no significant association between SI and incident ECI over up to 6 years of follow-up.

Discussion

SI is associated with higher prevalence, but not incident ECI. Future studies with large sample sizes need to further elucidate the relationship between SI and ECI.

Highlights

Sensory impairment is associated with high prevalence of early cognitive impairmentMultisensory impairment may pose a strong risk of early changes in cognitive functionIdentifying multisensory impairment may help early detection of dementia.

SUBMITTER: Cai Y

PROVIDER: S-EPMC10103182 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature

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Publications

Sensory impairment and algorithmic classification of early cognitive impairment.

Cai Yurun Y Schrack Jennifer A JA Gross Alden L AL Armstrong Nicole M NM Swenor Bonnielin K BK Deal Jennifer A JA Lin Frank R FR Wang Hang H Tian Qu Q An Yang Y Simonsick Eleanor M EM Ferrucci Luigi L Resnick Susan M SM Agrawal Yuri Y

Alzheimer's & dementia (Amsterdam, Netherlands) 20230414 2

<h4>Introduction</h4>Sensory impairment (SI) is linked to cognitive decline, but its association with early cognitive impairment (ECI) is unclear.<h4>Methods</h4>Sensory functions (vision, hearing, vestibular function, proprioception, and olfaction) were measured between 2012 and 2018 in 414 Baltimore Longitudinal Study of Aging (BLSA) participants (age 74 ± 9 years; 55% women). ECI was defined as 1 standard deviation below age-, sex-, race-, and education-specific mean performance in Card Rotat ...[more]

PMID: 37063388

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Dataset Information

Sensory impairment and algorithmic classification of early cognitive impairment.

Introduction

Methods

Results

Discussion

Highlights

Publications

Sensory impairment and algorithmic classification of early cognitive impairment.

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