Ontology highlight
ABSTRACT:
SUBMITTER: An S
PROVIDER: S-EPMC10107909 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
An Seungchan S Ko Hyejin H Jang Hongjun H Park In Guk IG Ahn Sungjin S Hwang Seok Young SY Gong Junpyo J Oh Soyeon S Kwak Soo Yeon SY Lee Yeonjin Y Kim Hyoungsu H Noh Minsoo M
ACS medicinal chemistry letters 20230306 4
Decreased circulating adiponectin levels are associated with an increased risk of human metabolic diseases. The chemical-mediated upregulation of adiponectin biosynthesis has been proposed as a novel therapeutic approach to managing hypoadiponectinemia-associated diseases. In preliminary screening, the natural flavonoid chrysin (<b>1</b>) exhibited adiponectin secretion-inducing activity during adipogenesis in human bone marrow mesenchymal stem cells (hBM-MSCs). Here, we provide the 7-prenylated ...[more]