Ontology highlight
ABSTRACT:
SUBMITTER: Malter JS
PROVIDER: S-EPMC10111655 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Translational research : the journal of laboratory and clinical medicine 20220923
Alzheimer's disease (AD) is an immense and growing public health crisis. Despite over 100 years of investigation, the etiology remains elusive and therapy ineffective. Despite current gaps in knowledge, recent studies have identified dysfunction or loss-of-function of Pin1, a unique cis-trans peptidyl prolyl isomerase, as an important step in AD pathogenesis. Here I review the functionality of Pin1 and its role in neurodegeneration. ...[more]