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SPOC domain proteins in health and disease.

ABSTRACT: Since it was first described >20 yr ago, the SPOC domain (Spen paralog and ortholog C-terminal domain) has been identified in many proteins all across eukaryotic species. SPOC-containing proteins regulate gene expression on various levels ranging from transcription to RNA processing, modification, export, and stability, as well as X-chromosome inactivation. Their manifold roles in controlling transcriptional output implicate them in a plethora of developmental processes, and their misregulation is often associated with cancer. Here, we provide an overview of the biophysical properties of the SPOC domain and its interaction with phosphorylated binding partners, the phylogenetic origin of SPOC domain proteins, the diverse functions of mammalian SPOC proteins and their homologs, the mechanisms by which they regulate differentiation and development, and their roles in cancer.

SUBMITTER: Appel LM

PROVIDER: S-EPMC10111866 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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SPOC domain proteins in health and disease.

Appel Lisa-Marie LM Benedum Johannes J Engl Magdalena M Platzer Sebastian S Schleiffer Alexander A Strobl Xué X Slade Dea D

Genes & development 20230316 5-6

Since it was first described >20 yr ago, the SPOC domain (Spen paralog and ortholog C-terminal domain) has been identified in many proteins all across eukaryotic species. SPOC-containing proteins regulate gene expression on various levels ranging from transcription to RNA processing, modification, export, and stability, as well as X-chromosome inactivation. Their manifold roles in controlling transcriptional output implicate them in a plethora of developmental processes, and their misregulation ...[more]

PMID: 36927757

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Spen regulates X chromosome inactivation (SPEN SPOC domain rescue)

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SPOC: a widely distributed domain associated with cancer, apoptosis and transcription.

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