Dataset Information

Plasma concentration of TMAO is an independent predictor of adverse outcomes in patients after acute myocardial infarction.

ABSTRACT:

Introduction

Plasma concentrations of gut microbial metabolites are associated with cardiomyocyte viability and platelet reactivity. We hypothesized that increased concentrations of gut metabolites may predict major adverse cardiac and cerebrovascular events (MACCE) after acute myocardial infarction (AMI).

Aim

The primary objective of this study was to evaluate the association between elevated plasma concentrations of gut metabolites and MACCE after AMI.

Material and methods

We compared plasma concentrations of gut metabolites (trimethylamine-N-oxide (TMAO) and indoxyl sulphate (IS)) and platelet reactivity in 57 patients with AMI and 27 healthy controls. We assessed the predictive value of gut metabolites for MACCE (stroke, recurrent AMI, death) over a median of 3.5-years.

Results

The concentrations of TMAO and IS did not differ between AMI patients and controls. The concentrations of TMAO and IS were higher in patients who developed MACCE than in those who did not (p ≤ 0.015 for all). The concentration of TMAO was the only independent predictor of MACCE in a multivariate analysis (OR = 35.041, 95% CI: 1.269-967.307, p = 0.036). Patients with the concentration of TMAO and indoxyl sulphate above the cut-off value predictive of MACCE had higher platelet activity (p ≤ 0.149 for all).

Conclusions

Increased plasma concentration of TMAO is an independent predictor of MACCE and may contribute to post-AMI cardiac dysfunction.

SUBMITTER: Gasecka A

PROVIDER: S-EPMC10114180 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

Plasma concentration of TMAO is an independent predictor of adverse outcomes in patients after acute myocardial infarction.

Gąsecka Aleksandra A Fidali Oliwia O Kłębukowska Aleksandra A Jasińska-Gniadzik Karolina K Szwed Piotr P Witkowska Karolina K Eyileten Ceren C Postuła Marek M Grabowski Marcin M Filipiak Krzysztof J KJ Ufnal Marcin M

Postepy w kardiologii interwencyjnej = Advances in interventional cardiology 20230123 1

<h4>Introduction</h4>Plasma concentrations of gut microbial metabolites are associated with cardiomyocyte viability and platelet reactivity. We hypothesized that increased concentrations of gut metabolites may predict major adverse cardiac and cerebrovascular events (MACCE) after acute myocardial infarction (AMI).<h4>Aim</h4>The primary objective of this study was to evaluate the association between elevated plasma concentrations of gut metabolites and MACCE after AMI.<h4>Material and methods</h ...[more]

PMID: 37090218

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Dataset Information

Plasma concentration of TMAO is an independent predictor of adverse outcomes in patients after acute myocardial infarction.

Introduction

Aim

Material and methods

Results

Conclusions

Publications

Plasma concentration of TMAO is an independent predictor of adverse outcomes in patients after acute myocardial infarction.

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