Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe K
PROVIDER: S-EPMC10115644 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Watanabe Kengo K Wilmanski Tomasz T Diener Christian C Earls John C JC Zimmer Anat A Lincoln Briana B Hadlock Jennifer J JJ Lovejoy Jennifer C JC Gibbons Sean M SM Magis Andrew T AT Hood Leroy L Price Nathan D ND Rappaport Noa N
Nature medicine 20230320 4
Multiomic profiling can reveal population heterogeneity for both health and disease states. Obesity drives a myriad of metabolic perturbations and is a risk factor for multiple chronic diseases. Here we report an atlas of cross-sectional and longitudinal changes in 1,111 blood analytes associated with variation in body mass index (BMI), as well as multiomic associations with host polygenic risk scores and gut microbiome composition, from a cohort of 1,277 individuals enrolled in a wellness progr ...[more]