Ontology highlight
ABSTRACT:
SUBMITTER: Dias AG
PROVIDER: S-EPMC10115655 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Dias Antonio G AG Atyeo Caroline C Loos Carolin C Montoya Magelda M Roy Vicky V Bos Sandra S Narvekar Parnal P Singh Tulika T Katzelnick Leah C LC Kuan Guillermina G Lauffenburger Douglas A DA Balmaseda Angel A Alter Galit G Harris Eva E
Science translational medicine 20220629 651
Preexisting cross-reactive antibodies have been implicated in both protection and pathogenesis during subsequent infections with different dengue virus (DENV) serotypes (DENV1-4). Nonetheless, humoral immune correlates and mechanisms of protection have remained elusive. Using a systems serology approach to evaluate humoral responses, we profiled plasma collected before inapparent or symptomatic secondary DENV3 infection from our pediatric cohort in Nicaragua. Children protected from symptomatic ...[more]