Dataset Information

Validation of two automated ASPECTS software on non-contrast computed tomography scans of patients with acute ischemic stroke.

ABSTRACT:

Purpose

The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) was designed for semi-quantitative assessment of early ischemic changes on non-contrast computed tomography (NCCT) for acute ischemic stroke (AIS). We evaluated two automated ASPECTS software in comparison with reference standard.

Methods

NCCT of 276 AIS patients were retrospectively reviewed (March 2018-June 2020). A three-radiologist consensus for ASPECTS was used as reference standard. Imaging data from both baseline and follow-up were evaluated for reference standard. Automated ASPECTS were calculated from baseline NCCT with 1-mm and 5-mm slice thickness, respectively. Agreement between automated ASPECTS and reference standard was assessed using intra-class correlation coefficient (ICC). Correlation of automated ASPECTS with baseline stroke severity (NIHSS) and follow-up ASPECTS were evaluated using Spearman correlation analysis.

Results

In score-based analysis, automated ASPECTS calculated from 5-mm slice thickness images agreed well with reference standard (software A: ICC = 0.77; software B: ICC = 0.65). Bland-Altman analysis revealed that the mean differences between automated ASPECTS and reference standard were ≤ 0.6. In region-based analysis, automated ASPECTS derived from 5-mm slice thickness images by software A showed higher sensitivity (0.60 vs. 0.54), lower specificity (0.91 vs. 0.94), and higher AUC (0.76 vs. 0.74) than those using 1-mm slice thickness images (p < 0.05). Automated ASPECTS derived from 5-mm slice thickness images by software B showed higher sensitivity (0.56 vs. 0.51), higher specificity (0.87 vs. 0.81), higher accuracy (0.80 vs. 0.73), and higher AUC (0.71 vs. 0.66) than those using 1-mm slice thickness images (p < 0.05). Automated ASPECTS were significantly associated with baseline NIHSS and follow-up ASPECTS.

Conclusion

Automated ASPECTS showed good reliability and 5 mm was the optimal slice thickness.

SUBMITTER: Chen Z

PROVIDER: S-EPMC10116051 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Validation of two automated ASPECTS software on non-contrast computed tomography scans of patients with acute ischemic stroke.

Chen Zhongping Z Shi Zhenzhen Z Lu Fei F Li Linna L Li Mingyang M Wang Shuo S Wang Wenxin W Li Yongxin Y Luo Yu Y Tong Dan D

Frontiers in neurology 20230406

<h4>Purpose</h4>The Alberta Stroke Program Early Computed Tomography Score (ASPECTS) was designed for semi-quantitative assessment of early ischemic changes on non-contrast computed tomography (NCCT) for acute ischemic stroke (AIS). We evaluated two automated ASPECTS software in comparison with reference standard.<h4>Methods</h4>NCCT of 276 AIS patients were retrospectively reviewed (March 2018-June 2020). A three-radiologist consensus for ASPECTS was used as reference standard. Imaging data fro ...[more]

PMID: 37090971

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Dataset Information

Validation of two automated ASPECTS software on non-contrast computed tomography scans of patients with acute ischemic stroke.

Purpose

Methods

Results

Conclusion

Publications

Validation of two automated ASPECTS software on non-contrast computed tomography scans of patients with acute ischemic stroke.

Similar Datasets

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