Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors.
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ABSTRACT:
SUBMITTER: Gao SQ
PROVIDER: S-EPMC10119609 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Publications
Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors.
Gao Shuang-Qi SQ Chen Jun-Quan JQ Zhou Hai-Yun HY Luo Lun L Zhang Bao-Yu BY Li Man-Ting MT He Hai-Yong HY Chen Chuan C Guo Ying Y
iScience 20230322 4
Deficits in astrocyte function contribute to major depressive disorder (MDD) and suicide, but the therapeutic effect of directly reactivating astrocytes for depression remains unclear. Here, specific gains and losses of astrocytic cell functions in the medial prefrontal cortex (mPFC) bidirectionally regulate depression-like symptoms. Remarkably, recombinant human Thrombospondin-1 (rhTSP1), an astrocyte-secreted protein, exerted rapidly antidepressant-like actions through tyrosine hydroxylase (Th ...[more]
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