Ontology highlight
ABSTRACT:
SUBMITTER: Mahnashi M
PROVIDER: S-EPMC10120551 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Journal of enzyme inhibition and medicinal chemistry 20231201 1
A novel series of multifunctional pyrazolo[3,4-d]pyrimidine-based glutamate analogs (<b>6a-l</b> and <b>7a,b</b>) have been designed and synthesized as antifolate anticancer agents. Among the tested compounds, <b>6i</b> exhibited the most potent anti-proliferative activity towards NSCLC, CNS, Ovarian, Prostate, Colon, Melanoma, Breast, and Renal cancers with good to weak cytostatic activity and non-lethal actions. <b>6i</b> demonstrated higher selectivity for cancer than normal cells. <b>6i</b> ...[more]