Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC10123345 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Wang Ruizhong R Kumar Brijesh B Bhat-Nakshatri Poornima P Khatpe Aditi S AS Murphy Michael P MP Wanczyk Kristen E KE Simpson Edward E Chen Duojiao D Gao Hongyu H Liu Yunlong Y Doud Emma H EH Mosley Amber L AL Nakshatri Harikrishna H
iScience 20230331 4
Skeletal muscle dysfunction or reprogramming due to the effects of the cancer secretome is observed in multiple malignancies. Although mouse models are routinely used to study skeletal muscle defects in cancer, because of species specificity of certain cytokines/chemokines in the secretome, a human model system is required. Here, we establish simplified multiple skeletal muscle stem cell lines (hMuSCs), which can be differentiated into myotubes. Using single nuclei ATAC-seq (snATAC-seq) and RNA- ...[more]