Dataset Information

Epizootic Hemorrhagic Disease Virus Serotype 8, Italy, 2022.

ABSTRACT: We describe the detection of epizootic hemorrhagic disease virus (EHDV) serotype 8 in cattle farms in Sardinia and Sicily in October-November 2022. The virus has a direct origin in North Africa; its genome is identical (>99.9% nucleotide sequence identity) to EHDV serotype 8 strains detected in Tunisia in 2021.

SUBMITTER: Lorusso A

PROVIDER: S-EPMC10124640 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Epizootic Hemorrhagic Disease Virus Serotype 8, Italy, 2022.

Lorusso Alessio A Cappai Stefano S Loi Federica F Pinna Luigia L Ruiu Angelo A Puggioni Giantonella G Guercio Annalisa A Purpari Giuseppa G Vicari Domenico D Sghaier Soufien S Zientara Stephan S Spedicato Massimo M Hammami Salah S Ben Hassine Thameur T Portanti Ottavio O Breard Emmanuel E Sailleu Corinne C Ancora Massimo M Di Sabatino Daria D Morelli Daniela D Calistri Paolo P Savini Giovanni G

Emerging infectious diseases 20230501 5

We describe the detection of epizootic hemorrhagic disease virus (EHDV) serotype 8 in cattle farms in Sardinia and Sicily in October-November 2022. The virus has a direct origin in North Africa; its genome is identical (>99.9% nucleotide sequence identity) to EHDV serotype 8 strains detected in Tunisia in 2021. ...[more]

PMID: 37081599

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Project description:Two strains of viruses, JC13C644 and JC13C673, were isolated from Culicoides tainanus collected in Jiangcheng County, Yunnan Province, situated along the border area shared by China, Laos, and Vietnam. JC13C644 and JC13C673 viruses can cause cytopathic effect (CPE) in mammalian cells BHK21 and Vero cells, and cause morbidity and mortality in suckling mice 48 h after intracerebral inoculation. Whole-genome sequencing was performed, yielding complete sequences for all 10 segments from Seg-1 (3942nt) to Seg-10 (810nt). Phylogenetic analysis of the sub-core-shell (T2) showed that the JC13C644 and JC13C673 viruses clustered with the Epizootic Hemorrhagic Disease Virus (EHDV) isolated from Japan and Australia, with nucleotide and amino acid homology of 93.1% to 98.3% and 99.2% to 99.6%, respectively, suggesting that they were Eastern group EHDV. The phylogenetic analysis of outer capsid protein (OC1) and outer capsid protein (OC2) showed that the JC13C644 and JC13C673 viruses were clustered with the EHDV-10 isolated from Japan in 1998, with the nucleotide homology of 98.3% and 98.5%, and the amino acid homology of 99.6% and 99.6-99.8%, respectively, indicating that they belong to the EHDV-10. Seroepidemiological survey results demonstrated that JC13C644 virus-neutralizing antibodies were present in 29.02% (177/610) of locally collected cattle serum and 11.32% (89/786) of goat serum, implying the virus's presence in Jiangcheng, Yunnan Province. This finding suggests that EHDV-10 circulates not only among blood-sucking insects in nature but also infects local domestic animals in China. Notably, this marks the first-ever isolation of the virus in China and its discovery outside of Japan since its initial isolation from Japanese cattle. In light of these results, it is evident that EHDV Serotype 10 exists beyond Japan, notably in the natural vectors of southern Eurasia, with the capacity to infect local cattle and goats. Therefore, it is imperative to intensify the surveillance of EHDV infection in domestic animals, particularly focusing on the detection and monitoring of new virus serotypes that may emerge in the region and pose risks to animal health.

Dataset Information

Epizootic Hemorrhagic Disease Virus Serotype 8, Italy, 2022.

Publications

Epizootic Hemorrhagic Disease Virus Serotype 8, Italy, 2022.

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