Ontology highlight
ABSTRACT:
SUBMITTER: Sano FK
PROVIDER: S-EPMC10129325 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
eLife 20230425
The endothelin ET<sub>B</sub> receptor is a promiscuous G-protein coupled receptor that is activated by vasoactive peptide endothelins. ET<sub>B</sub> signaling induces reactive astrocytes in the brain and vasorelaxation in vascular smooth muscle. Consequently, ET<sub>B</sub> agonists are expected to be drugs for neuroprotection and improved anti-tumor drug delivery. Here, we report the cryo-electron microscopy structure of the endothelin-1-ET<sub>B</sub>-G<sub>i</sub> complex at 2.8 Å resolutio ...[more]