Dataset Information

Procalcitonin-guided antibiotic prescription in patients with COVID-19: a multicentre observational cohort study.

ABSTRACT:

Background

Despite the low rate of bacterial co-infection, antibiotics are very commonly prescribed in hospitalised COVID-19 patients.

Research question

Does the use of a PCT-guided antibiotic protocol safely reduce the use of antibiotics in patients with a COVID-19 infection?

Study design and methods

In this multicentre cohort, 3 groups of COVID-19 patients were compared in terms of antibiotic consumption, namely one group treated based on a PCT-algorithm in one hospital (n=216) and 2 control groups, consisted of patients from the same hospital (n=57) and of patients from 3 similar hospitals (n=486) without PCT measurements during the same period. The primary endpoint was antibiotic prescription in the first week of admission.

Results

Antibiotic prescription during the first 7 days was 26.8% in the PCT-group, 43.9% in the non-PCT group in the same hospital and 44.7% in the non-PCT group in other hospitals. Patients in the PCT-group had lower odds of receiving antibiotics in the first 7 days of admission (OR 0.33; 0.16 - 0.66 compared to the same hospital and OR 0.42; 95% CI 0.28 - 0.62 compared to the other hospitals). The proportion of patients receiving antibiotic prescription during the total admission was respectively 35.2%, 43.9% and 54.5%. The PCT-group had lower odds of receiving antibiotics during the total admission only when compared to the other hospitals (OR 0.23; 95%CI 0.08 - 0.63). There were no significant differences in other secondary endpoints, except for re-admission in the PCT-group versus the other hospitals group.

Interpretation

PCT-guided antibiotic prescription reduces antibiotic prescription rates in hospitalised patients with COVID-19, without major safety concerns.

SUBMITTER: Hessels L

PROVIDER: S-EPMC10132833 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Publications

Procalcitonin-Guided Antibiotic Prescription in Patients With COVID-19: A Multicenter Observational Cohort Study.

Hessels Lisa M LM Speksnijder Esther E Paternotte Nienke N van Huisstede Astrid A Thijs Willemien W Scheer Margot M van der Steen-Dieperink Mariëlle M Knarren Lieve L van Den Bergh Joop P JP Winckers Kristien K Henry Ronald R Simsek Suat S Boersma Wim G WG

Chest 20230426 3

<h4>Background</h4>Despite the low rate of bacterial coinfection, antibiotics are very commonly prescribed in hospitalized patients with COVID-19.<h4>Research question</h4>Does the use of a procalcitonin (PCT)-guided antibiotic protocol safely reduce the use of antibiotics in patients with a COVID-19 infection?<h4>Study design and methods</h4>In this multicenter cohort, three groups of patients with COVID-19 were compared in terms of antibiotic consumption, namely one group treated based on a PC ...[more]

PMID: 37116748

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