Ontology highlight
ABSTRACT:
SUBMITTER: Koehler Leman J
PROVIDER: S-EPMC10133388 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Koehler Leman Julia J Szczerbiak Pawel P Renfrew P Douglas PD Gligorijevic Vladimir V Berenberg Daniel D Vatanen Tommi T Taylor Bryn C BC Chandler Chris C Janssen Stefan S Pataki Andras A Carriero Nick N Fisk Ian I Xavier Ramnik J RJ Knight Rob R Bonneau Richard R Kosciolek Tomasz T
Nature communications 20230426 1
For the past half-century, structural biologists relied on the notion that similar protein sequences give rise to similar structures and functions. While this assumption has driven research to explore certain parts of the protein universe, it disregards spaces that don't rely on this assumption. Here we explore areas of the protein universe where similar protein functions can be achieved by different sequences and different structures. We predict ~200,000 structures for diverse protein sequences ...[more]