Ontology highlight
ABSTRACT:
SUBMITTER: Takagi T
PROVIDER: S-EPMC10139117 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Takagi Tadataka T Fujiwara-Tani Rina R Mori Shiori S Kishi Shingo S Nishiguchi Yukiko Y Sasaki Takamitsu T Ogata Ruiko R Ikemoto Ayaka A Sasaki Rika R Ohmori Hitoshi H Luo Yi Y Bhawal Ujjal Kumar UK Sho Masayuki M Kuniyasu Hiroki H
International journal of molecular sciences 20230419 8
Although gemcitabine (GEM) is widely used in chemotherapy for pancreatic ductal adenocarcinoma (PDA), drug resistance restricts its clinical effectiveness. To examine the mechanism of GEM resistance, we established two GEM-resistant cell lines from human PDA cells by continuous treatment with GEM and CoCl<sub>2</sub>-induced chemical hypoxia. One resistant cell line possessed reduced energy production and decreased mitochondrial reactive oxygen species levels, while the other resistant cell line ...[more]