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Autophagy in graves' ophthalmopathy.


ABSTRACT: Graves' ophthalmopathy (GO) is an inflammatory autoimmune disease that affects the eyes. It can significantly alter the quality of life in patients because of its distinctive pathological appearance and the effect on vision. To date, the exact pathological mechanism of GO has not been explicitly discovered. However, several studies have associated autophagy with this disease. Autophagy is a catabolic process that helps maintain homeostasis in all organisms by protecting the cells and tissues from various endogenous and exogenous stress factors. Based on our results, patients affected with GO have comparatively elevated levels of autophagy, which critically affects the pathological mechanism of the GO. In this review, we have summarized the autophagy mechanism in the pathogenesis of GO.

SUBMITTER: Chen YQ 

PROVIDER: S-EPMC10140433 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Autophagy in graves' ophthalmopathy.

Chen Yu-Qing YQ   Gao Lian-Di LD   Liu Yi-Lin YL   Shen Ya Y   Diao Jia-Le JL   Yang Wei-Hua WH   Wei Rui-Li RL  

Frontiers in cell and developmental biology 20230414


Graves' ophthalmopathy (GO) is an inflammatory autoimmune disease that affects the eyes. It can significantly alter the quality of life in patients because of its distinctive pathological appearance and the effect on vision. To date, the exact pathological mechanism of GO has not been explicitly discovered. However, several studies have associated autophagy with this disease. Autophagy is a catabolic process that helps maintain homeostasis in all organisms by protecting the cells and tissues fro  ...[more]

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