Ontology highlight
ABSTRACT:
SUBMITTER: Neth BJ
PROVIDER: S-EPMC10141140 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Neth Bryan J BJ Webb Mason J MJ Parney Ian F IF Sener Ugur T UT
Pharmaceutics 20230403 4
Glioblastoma (GBM) is the most common malignant primary brain tumor and confers a dismal prognosis. With only two FDA-approved therapeutics showing modest survival gains since 2005, there is a great need for the development of other disease-targeted therapies. Due, in part, to the profound immunosuppressive microenvironment seen in GBMs, there has been a broad interest in immunotherapy. In both GBMs and other cancers, therapeutic vaccines have generally yielded limited efficacy, despite their th ...[more]