Ontology highlight
ABSTRACT:
SUBMITTER: Rodriguez CA
PROVIDER: S-EPMC10146539 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Rodriguez Carly A CA Lodi Sara S Horsburgh C Robert CR Mitnick Carole D CD Bastard Mathieu M Huerga Helena H Khan Uzma U Rich Michael M Seung Kwonjune J KJ Atwood Sidney S Manzur-Ul-Alam Md M Melikyan Nara N Mpinda Stephanie S Myint Zaw Z Naidoo Yugandran Y Petrosyan Ofelya O Salahuddin Naseem N Sarfaraz Samreen S Vilbrun Stalz Charles SC Yae Kalkidan K Achar Jay J Ahmed Saman S Algozhina Elena E Beauchamp Jude J de Guadelupe Perea Moreno Sara S Gulanbaeva Munara M Gergedava Marika M Indah Sari Cut Yulia CY Hewison Catherine C Khan Palwasha P Franke Molly F MF
PLOS global public health 20230428 4
Clarity about the role of delamanid in longer regimens for multidrug-resistant TB is needed after discordant Phase IIb and Phase III randomized controlled trial results. The Phase IIb trial found that the addition of delamanid to a background regimen hastened culture conversion; the results of the Phase III trial were equivocal. We evaluated the effect of adding delamanid for 24 weeks to three-drug MDR/RR-TB regimens on two- and six-month culture conversion in the endTB observational study. We u ...[more]