Ontology highlight
ABSTRACT:
SUBMITTER: Shah AM
PROVIDER: S-EPMC10146891 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Science advances 20230428 17
Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children that resembles developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate despite expression of the myogenic determination protein MYOD. The TWIST2 transcription factor is frequently overexpressed in fusion-negative RMS (FN-RMS). TWIST2 blocks differentiation by inhibiting MYOD activity in myoblasts, but its role in FN-RMS pathogenesis is incompletely understood. Here, we show that knockdown of TWIST2 ...[more]