LZY3016, a novel geldanamycin derivative, inhibits tumor growth in an MDA-MB-231 xenograft model.
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ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC10155491 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
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LZY3016, a novel geldanamycin derivative, inhibits tumor growth in an MDA-MB-231 xenograft model.
Li Zhenyu Z Jia Lejiao L Tang Hui H Shen Yuemao Y Shen Chengwu C
RSC advances 20230503 20
A novel geldanamycin derivative LZY3016 was synthesized as an antitumor agent. Compound LZY3016 exhibited potent anti-proliferation activity toward MDA-MB-231 (IC<sub>50</sub> = 0.06 μM), which was more effective than positive drug 17-AAG. <i>In vivo</i> hepatotoxicity assay displayed that serum AST/ALT levels in LZY3016-treated mice were both significantly less than those in the geldanamycin (GA) group. LZY3016 showed potent antitumor activity in an MDA-MB-231 xenograft mouse model, suggesting ...[more]
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