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Salmonella typhimurium may support cancer treatment: a review.

ABSTRACT: Antitumour treatments are evolving, including bacteria-mediated cancer therapy which is concurrently an ancient and cutting-edge approach. Salmonella typhimurium is a widely studied bacterial species that colonizes tumor tissues, showing oncolytic and immune system-regulating properties. It can be used as a delivery vector for genes and drugs, supporting conventional treatments that lack tumor-targeting abilities. This article summarizes recent evidence on the anticancer mechanisms of S. typhimurium alone and in combination with other anticancer treatments, suggesting that it may be a suitable approach to disease management.

SUBMITTER: Yang Z

PROVIDER: S-EPMC10160236 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Salmonella typhimurium may support cancer treatment: a review.

Yang Zeyu Z Zou Ling L Yue Bing B Hu Minwei M

Acta biochimica et biophysica Sinica 20230201 3

Antitumour treatments are evolving, including bacteria-mediated cancer therapy which is concurrently an ancient and cutting-edge approach. Salmonella typhimurium is a widely studied bacterial species that colonizes tumor tissues, showing oncolytic and immune system-regulating properties. It can be used as a delivery vector for genes and drugs, supporting conventional treatments that lack tumor-targeting abilities. This article summarizes recent evidence on the anticancer mechanisms of ...[more]

PMID: 36786073

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