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Activities of an intravenous formulation of itraconazole in experimental disseminated Aspergillus, Candida, and Cryptococcus infections.

ABSTRACT: An intravenous (i.v.) formulation of itraconazole was evaluated in disseminated fungal infection models in guinea pigs. In acute disseminated Candida albicans and Aspergillus fumigatus infections, treatment at 5 mg/kg of body weight twice a day (b.i.d.) significantly prolonged survival. In these models and in animals with chronic disseminated cryptococcosis, itraconazole given i.v. at 2.5 and 5 mg/kg b.i.d. greatly reduced the proportions of organs with culture-detectable fungal burdens. The efficacy of i.v. itraconazole in these animal models justifies its further investigation for the treatment of life-threatening mycoses in humans.

SUBMITTER: Odds FC

PROVIDER: S-EPMC101627 | biostudies-literature | 2000 Nov

REPOSITORIES: biostudies-literature

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Activities of an intravenous formulation of itraconazole in experimental disseminated Aspergillus, Candida, and Cryptococcus infections.

Odds F C FC Oris M M Van Dorsselaer P P Van Gerven F F

Antimicrobial agents and chemotherapy 20001101 11

An intravenous (i.v.) formulation of itraconazole was evaluated in disseminated fungal infection models in guinea pigs. In acute disseminated Candida albicans and Aspergillus fumigatus infections, treatment at 5 mg/kg of body weight twice a day (b.i.d.) significantly prolonged survival. In these models and in animals with chronic disseminated cryptococcosis, itraconazole given i.v. at 2.5 and 5 mg/kg b.i.d. greatly reduced the proportions of organs with culture-detectable fungal burdens. The eff ...[more]

PMID: 11036047

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Early-expressed chemokines predict kidney immunopathology in experimental disseminated Candida albicans infections.

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Phenotypic Diversity of Cryptococcus neoformans var. neoformans Clinical Isolates from Localized and Disseminated Infections.

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| S-EPMC8316071 | biostudies-literature

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| S-EPMC4301749 | biostudies-literature

Bigger Data Approach to Analysis of Essential Oils and Their Antifungal Activity against Aspergillus niger, Candida albicans, and Cryptococcus neoformans.

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| S-EPMC6718987 | biostudies-literature

Functional Nanocarriers for Delivering Itraconazole Against Fungal Intracellular Infections.

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| S-EPMC8274696 | biostudies-literature

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