Ontology highlight
ABSTRACT:
SUBMITTER: Lai HY
PROVIDER: S-EPMC10172115 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Lai Huei-Yi HY Yu Yen-Hsin YH Jhou Yu-Ting YT Liao Chia-Wei CW Leu Jun-Yi JY
Nature ecology & evolution 20230330 5
Essential genes are commonly assumed to function in basic cellular processes and to change slowly. However, it remains unclear whether all essential genes are similarly conserved or if their evolutionary rates can be accelerated by specific factors. To address these questions, we replaced 86 essential genes of Saccharomyces cerevisiae with orthologues from four other species that diverged from S. cerevisiae about 50, 100, 270 and 420 Myr ago. We identify a group of fast-evolving genes that often ...[more]